Explore the relationship between different types of dementia and biomarkers and head image structures Lead Investigator: Yingren Mai Institution : Sun Yat-sen University E-Mail : maiyr3@mail2.sysu.edu.cn Proposal ID : 1421 Proposal Description: Observe the biomarkers and brain structure changes in the development of Alzheimer's disease, and explore sensitive indicators for the diagnosis of AD disease or indicators for predicting AD disease.